Yasuko Manabe

Title: Yasuko Manabe: Innovator in Chemical Processes

Introduction

Yasuko Manabe is a prominent inventor based in Tokyo, Japan. She has made significant contributions to the field of chemical processes, particularly in the production of cephem derivatives. With a total of 2 patents, her work has garnered attention for its industrial applications.

Latest Patents

Yasuko Manabe's latest patents include a process for producing 3-chloromethyl-3-cephem derivatives. This innovative method outlines an industrially advantageous process for producing 3-chloromethyl-3-cephem derivative crystals. The process involves several steps, starting with the reaction of a thiazolineazetidinone derivative with a sulfonyl halide in the presence of an acid. This is followed by the reaction of the resulting azetidinone derivative with a chlorinating agent, and finally, the recovery of the 3-chloromethyl-3-cephem derivative in crystalline form.

Another notable patent is the process for preparing crystalline 3-chloromethyl-3-cephem derivatives. This method allows for the reaction of a chlorinated azetidinone derivative with an alcoholate in a solvent containing alcohols and ethers, resulting in the preparation of the desired cephem derivative.

Career Highlights

Yasuko Manabe is currently associated with Nippon Chemical Industrial Co., Ltd. Her work at this company has been instrumental in advancing chemical processes and enhancing production efficiency.

Collaborations

Throughout her career, Yasuko has collaborated with notable colleagues, including Nobuo Matsumoto and Hiroshi Kawakabe. These collaborations have contributed to her innovative approaches and successful patent applications.

Conclusion

Yasuko Manabe stands out as a significant figure in the field of chemical innovation. Her contributions to the production of cephem derivatives reflect her expertise and commitment to advancing industrial processes.