Yanping Wang

Title: Yanping Wang: Innovator in Bispecific Antibodies

Introduction

Yanping Wang is a notable inventor based in Frederick, MD (US). He has made significant contributions to the field of biotechnology, particularly in the development of bispecific antibodies. With a total of 2 patents, his work is paving the way for advancements in targeted therapies.

Latest Patents

One of Yanping Wang's latest patents is focused on protease cleavable bispecific antibodies and their uses. This invention provides recombinant bispecific antibodies designed to bind to a surface antigen on target cells and to an activating component on immune cells, such as T cells. The bispecific antibodies consist of two polypeptide chains that contain Fv and Fab as antigen-binding fragments, along with a modified Fc region to facilitate heterodimer formation. In one embodiment, these antibodies include protease cleavage sites and/or motifs that cause steric occlusion of the antigen binding sites, ensuring activation only in specific environments, such as near a tumor. Additionally, the antibodies may comprise modified sequences that confer reduced binding affinity to CDS and/or cross-reactive binding to CDS on cells from different species.

Career Highlights

Yanping Wang is currently associated with Zhejiang Shimai Pharmaceutical Co., Ltd. His innovative work in the field of bispecific antibodies has garnered attention and recognition within the scientific community.

Collaborations

He collaborates with notable colleagues, including Weizao Chen and Zuoxiang Xiao, who contribute to the research and development efforts in their field.

Conclusion

Yanping Wang's contributions to the development of bispecific antibodies represent a significant advancement in targeted therapies. His innovative approach and collaborative efforts continue to influence the biotechnology landscape.