Location History:
- Mayfield Heights, OH (US) (1998 - 1999)
- Pepper Pike, OH (US) (2002 - 2004)
Company Filing History:
3 out of 1,041 
1 out of 15,528 
Years Active: 1998-2004
Title: Yan Xu: Innovator in Lymphocyte Activation and Gynecological Carcinoma Detection
Introduction
Yan Xu is a notable inventor based in Pepper Pike, OH (US), recognized for his contributions to the fields of immunology and oncology. He holds a total of 4 patents, showcasing his innovative approaches to medical diagnostics and therapeutic methods.
Latest Patents
One of Yan Xu's latest patents is titled "Methods for modulating the activation of a lymphocyte expressed G protein coupled receptor involved in cell proliferation, autoimmunity and inflammation." This invention describes ligands and methods for modulating a G protein-coupled receptor (GPCR) known as G2A. The receptor is significant as its genetic ablation can lead to the development of autoimmunity. The patent reveals that lysophosphatidylcholine (LPC) serves as a high-affinity ligand for G2A, while sphingosylphosphorylcholine (SPC) acts as a lower affinity ligand. The activation of G2A is linked to various physiological processes, including cell proliferation, autoimmunity, and inflammation, making the methods outlined in this patent valuable for diagnostic and therapeutic applications.
Another significant patent by Yan Xu is the "Method of detecting gynecological carcinomas." This patent provides methods for detecting or diagnosing gynecological carcinomas in patients. One method involves assaying for the presence of lysophosphatidic acid in a plasma sample, which is useful for detecting ovarian, cervical, endometrial, and peritoneal carcinomas. The method includes providing a blood specimen, obtaining a plasma sample while minimizing the release of lysophosphatidic acid, extracting lipids, and detecting the presence of lysophosphatidic acid in the lipid.
Career Highlights
Throughout his career, Yan Xu has worked with prestigious institutions, including the Cleveland Clinic Foundation and the University of California. His work has significantly impacted the understanding and treatment of various medical conditions.
Collaborations
Yan Xu has collaborated with notable colleagues, including Graham Casey and Owen N Witte, contributing to advancements in his field.
Conclusion
Yan Xu's innovative patents and career achievements highlight his significant contributions to medical science, particularly in the areas of immunology and cancer detection. His work continues to pave the way for advancements in diagnostic and therapeutic methods.