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Years Active: 2020-2025
Title: Yan Shi: Innovator in Cancer Research
Introduction
Yan Shi is a prominent inventor based in Tampa, Florida, known for his significant contributions to cancer research. With a total of 3 patents, he has developed innovative solutions aimed at disrupting critical protein-protein interactions involved in cancer progression.
Latest Patents
One of Yan Shi's latest patents focuses on B-catenin/B-cell Lymphoma 9 protein-protein interaction inhibiting peptidomimetics. This patent discloses a series of helical sulfono-γ-AApeptides that mimic the binding mode of the α-helical HD2 domain of B-Cell Lymphoma 9 (BCL9). These sulfono-γ-AApeptides can structurally and functionally mimic the α-helical domain of BCL9, selectively disrupting β-catenin/BCL9 PPIs with enhanced potency. Remarkably, these peptides can enter cancer cells, bind with β-catenin, and exhibit excellent cellular activity, proving to be much more potent than the BCL9 peptide. Furthermore, enzymatic stability studies have shown the remarkable stability of these helical sulfono-γ-AApeptides, with no degradation in the presence of pronase for 24 hours, augmenting their biological potential.
Another significant patent involves a one-bead-two-compound macrocyclic library and methods of preparation and use. This combinatorial synthesis technique provides libraries of macrocyclic peptidomimetic compounds and compositions that serve as ligands for the Ephrin type-A receptor 2 (EphA2). The one-bead-two-compound technique and the resulting libraries of macrocyclic compounds are valuable as research tools in drug discovery and for treating or preventing a range of diseases or disorders.
Career Highlights
Yan Shi has worked with esteemed institutions such as the University of South Florida and the H. Lee Moffitt Cancer Center and Research Institute, Inc. His work in these organizations has significantly advanced the field of cancer research and drug development.
Collaborations
Throughout his career, Yan Shi has collaborated with notable colleagues, including Jianfeng Cai and Peng Sang. These collaborations have fostered innovative research and development in the field.
Conclusion
Yan Shi's contributions to cancer research through his innovative patents and collaborations highlight his role as a leading inventor in the field.