Yajun Guo

Title: Yajun Guo: Innovator in Biomedicine

Introduction

Yajun Guo is a prominent inventor based in Shanghai, China. He has made significant contributions to the field of biomedicine, particularly through his innovative patents. With a total of 2 patents, Guo's work addresses critical challenges in cancer treatment.

Latest Patents

One of Guo's latest patents is a bifunctional fusion protein targeting CD47 and PD-L1. This innovative protein aims to improve the efficacy of cancer treatments, especially for low immunogenic tumors. By combining a CD47-binding moiety and a PD-L1-binding moiety linked by a disulfide bond, the fusion protein effectively blocks the binding of CD47 to SIRPa and PD-L1 to PD-1. This dual action not only activates macrophage phagocytosis of tumor cells but also enhances antigen presentation in innate immunity. Furthermore, it promotes tumor-specific T cell activation in acquired immunity while exhibiting lower hematological toxicity. The fusion protein demonstrates better anti-tumor efficacy and safety compared to traditional therapies, providing a promising avenue for future cancer treatments.

Another significant patent involves a method for preparing a dabigatran etexilate intermediate. This method includes reacting a specific compound with a C-Calkyl alcohol solution of methylamine in an organic solvent. The process is characterized by its simplicity, ease of operation, high yield, and suitability for industrial production. This innovation contributes to the pharmaceutical industry by streamlining the preparation of important medicinal compounds.

Career Highlights

Yajun Guo has worked with notable companies such as Taizhou Mabtech Pharmaceutical Co., Ltd. and the Shanghai Institute of Pharmaceutical Industry. His experience in these organizations has allowed him to develop and refine his innovative ideas in the pharmaceutical sector.

Collaborations

Guo has collaborated with several professionals in his field, including Hanbin Shan and Xueyan Zhu. These partnerships have facilitated the exchange of ideas and expertise, further enhancing the impact of his work.

Conclusion

Yajun Guo's contributions to biomedicine through his innovative patents highlight his role as a leading inventor in the field. His work not only addresses significant challenges in cancer treatment but also paves the way for future advancements in pharmaceutical research.