The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 30, 2018
Filed:
Jul. 03, 2014
Shanghai Institute of Pharmaceutical Industry, Shanghai, CN;
China State Institute of Pharmaceutical Industry, Shanghai, CN;
Chia Tai Tianqing Pharmaceutical Group Co., Ltd., Lianyungang, CN;
Yajun Guo, Shanghai, CN;
Hanbin Shan, Shanghai, CN;
Xueyan Zhu, Shanghai, CN;
Zhedong Yuan, Shanghai, CN;
Xiong Yu, Shanghai, CN;
Meng Guo, Lianyungang, CN;
Mingtong Hu, Lianyungang, CN;
Duzheng Wang, Lianyungang, CN;
Yu Huang, Shanghai, CN;
SHANGHAI INSTITUTE OF PHARMACEUTICAL INDUSTRY, Jingan District, Shanghai, CN;
CHINA STATE INSTITUTE OF PHARMACEUTICAL INDUSTRY, Pudong New Area, Shanghai, CN;
CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD., Lianyungang, Jiangsu Province, CN;
Abstract
Disclosed are a method for preparing a dabigatran etexilate intermediate, and an intermediate compound. The method for preparing a dabigatran etexilate intermediate 4 comprises: reacting a compound 3 with a C-Calkyl alcohol solution of methylamine in an organic solvent, wherein, X=chlorine, bromine, or iodine. Also disclosed are an intermediate compound 3 and a preparation method thereof. The method for preparing a dabigatran etexilate intermediate of the present invention has the advantages of simple process, easy operation, high yield, and easy purification, thus being suitable for industrial production.