Xuechuan Hong

Title: Innovations of Xuechuan Hong in Molecular Imaging

Introduction

Xuechuan Hong is a prominent inventor based in Wuhan, China. He has made significant contributions to the field of molecular imaging and photothermal therapy. With a total of three patents to his name, his work focuses on developing small molecule dyes that enhance imaging capabilities.

Latest Patents

One of Xuechuan Hong's latest patents involves a small molecule dye designed for use in imaging within the near-infrared window, specifically between 1000 nm and 1700 nm wavelengths. This innovative dye is not only useful for photoacoustic imaging but also for photothermal therapy. The structure of the dye features a donor-acceptor-donor (D-A-D) fluorescent compound core, along with side chains that render the compounds water-soluble and easily conjugated to hydrophilic polymers and targeting ligands. Additionally, the compound CH1055 can be PEGylated, conjugated to a targeting ligand, or conjugated to taurine. Key steps in assembling the core structure included a cross-Suzuki coupling reaction, iron reduction, and N-thionylaniline induced ring closure. Four carboxylic acid groups were introduced into the D-A-D type fluorescent compound to enhance aqueous solubility and facilitate conjugation to targeting ligands.

Career Highlights

Xuechuan Hong has worked at notable institutions such as Leland Stanford Junior University and Yanti University. His experience in these prestigious organizations has contributed to his expertise in the field of molecular imaging.

Collaborations

Xuechuan has collaborated with esteemed colleagues, including Zhen Cheng and Hongjie Dai, further enriching his research and innovations.

Conclusion

Xuechuan Hong's work in developing small molecule dyes for molecular imaging and photothermal therapy showcases his innovative spirit and dedication to advancing scientific knowledge. His contributions are paving the way for future advancements in the field.