Xiuwen Zhong

Title: Xiuwen Zhong and a More Efficient Selamectin Synthesis Method.

Introduction

Xiuwen Zhong is an inventor associated with Hangzhou, China. His work includes a patent for a selamectin synthesis method designed to simplify production and improve its efficiency.

Latest Patents

Zhong’s patent, “Synthesis Method for Selamectin,” describes a process that oxidizes doramectin with manganese dioxide, followed by oximation and desugaring in one step using an aqueous hydroxylamine hydrochloride solution. The resulting material is selectively reduced with hydrogen in the presence of Wilkinson’s catalyst.

The method first converts doramectin to a carbonyl group to reduce impurities in later reactions. It uses tert-butyl alcohol, whose greater steric hindrance helps avoid transesterification impurities. Recrystallizing the crude product before the final hydrogenation step also helps reduce costs.

The application reports an overall yield of 57% and product purity of 97.11%, with all impurities meeting Pharmacopoeia requirements. It presents the process as a simpler, more economical method suitable for industrial production. Zhong is associated with 1 patent.

Career Highlights

Zhong’s listed affiliations include Zhejiang Rongyao Biotech Co., Ltd. and Zhejiang University. His patent reflects work on improving the efficiency and practicality of pharmaceutical synthesis.

Collaborations

The listed coworkers associated with Zhong include Lei Zhang and Youchun Huang.

Conclusion

Xiuwen Zhong’s selamectin synthesis patent outlines a streamlined process that combines impurity control, reported high product purity, and industrial-production potential.