Xiumin Zhao

Title: Xiumin Zhao: Innovator in Pharmaceutical Chemistry

Introduction

Xiumin Zhao is a notable inventor based in San Diego, California. He has made significant contributions to the field of pharmaceutical chemistry, particularly in the development of novel compounds with therapeutic potential. With a total of four patents to his name, Zhao's work focuses on enhancing drug-like properties of various compounds.

Latest Patents

One of Zhao's latest patents involves thiazolyl mGluR5 antagonists and methods for their use. This invention identifies a unique series of compounds that exhibit special advantages in terms of drug-like properties. These compounds demonstrate enhanced potency, pharmacokinetics, selectivity, and in vivo receptor occupancy properties. Specifically, the selection of a 1,3-thiazol-2-yl ring member linked by an ethynylene to the 3 position of a pyridyl ring or the 5 position of a pyrimidinyl ring results in compounds with superior drug-like characteristics. The invention also includes pharmaceutically acceptable salt forms of these heterocyclic compounds, particularly chloride salts and trifluoroacetate salts.

Career Highlights

Throughout his career, Xiumin Zhao has worked with prominent companies in the pharmaceutical industry, including Merck Sharp & Dohme Corporation and Merck & Company, Inc. His experience in these organizations has contributed to his expertise in drug development and innovation.

Collaborations

Zhao has collaborated with several professionals in his field, including Bowei Wang and Jeannie M Arruda, who is a woman. These collaborations have likely enriched his research and development efforts.

Conclusion

Xiumin Zhao's innovative work in pharmaceutical chemistry, particularly in the area of thiazolyl mGluR5 antagonists, showcases his commitment to advancing drug development. His contributions are significant in the pursuit of effective therapeutic solutions.