Company Filing History:
Years Active: 2010-2018
Title: Innovations of Xingwu Teng in Pulmonary Research
Introduction
Xingwu Teng is a prominent inventor based in Baltimore, MD, known for his significant contributions to pulmonary research. He holds five patents that focus on methods for promoting wound healing and treating pulmonary hypertension. His work has implications for understanding and addressing critical health issues related to lung function.
Latest Patents
One of Teng's latest patents is a method of promoting wound healing with a hypoxia-induced mitogenic factor (HIMF). This research reveals that FIZZ1/RELMα is inducible by hypoxia in the lung, with its expression found in the pulmonary vasculature, bronchial epithelial cells, and type II pneumocytes. The recombinant FIZZ1/RELMα protein stimulates rat pulmonary microvascular smooth muscle cell (RPSM) proliferation in a dose-dependent manner. HIMF strongly activates Akt phosphorylation, and the phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 inhibits this activation, demonstrating that the PI3K/Akt pathway mediates the proliferative effect of HIMF. Additionally, HIMF exhibits angiogenic and vasoconstrictive activity, increasing pulmonary arterial pressure and vascular resistance more potently than endothelin-1 or angiotensin II.
Another significant patent by Teng is a method for treating pulmonary hypertension, which also centers around the role of FIZZ1/RELMα in the lung. The findings from this research further emphasize the importance of HIMF in pulmonary health and its potential therapeutic applications.
Career Highlights
Xingwu Teng is affiliated with The Johns Hopkins University, where he conducts his research and develops innovative solutions for pulmonary conditions. His work has garnered attention in the scientific community, contributing to advancements in understanding lung-related diseases.
Collaborations
Teng collaborates with notable colleagues, including Roger A. Johns and Dechun Li, who contribute to his research endeavors and enhance the impact of his work in the field of pulmonary research.
Conclusion
Xingwu Teng's innovative research and patents significantly advance the understanding of pulmonary health and treatment options. His contributions are vital for developing new therapeutic strategies for lung-related conditions.