Location History:
- West Haven, CT (US) (2001 - 2005)
- Hamden, CT (US) (2011 - 2019)
Company Filing History:
4 out of 1,327 
2 out of 17 
1 out of 1,627 
Years Active: 2001-2019
Title: The Innovative Contributions of Inventor Xinghua Pan
Introduction
Xinghua Pan, an accomplished inventor based in Hamden, CT, has made significant strides in the field of genomics with a total of eight patents to his name. His work primarily focuses on advanced methodologies for analyzing chromatin and DNA methylation, which are essential for understanding genetic structures at a single-cell level. This article delves into his latest patents, career highlights, and collaborations that underline his contributions to the scientific community.
Latest Patents
Among Xinghua Pan's notable patents is a method for closed chromatin mapping and DNA methylation analysis for single cells. This invention details techniques for identifying DNase I Hyper-Resistant Sites (DHRS) and characterizing the DNA methylation status of differentially methylated regions (DMRs) such as CpG islands. These methods are particularly effective for analyzing genomic DNA derived from low quantities of cells, which can be fewer than 1,000, 100, or even as low as ten or one cell. The techniques enable researchers to generate detailed chromatin and methylation profiles, which can be pivotal in drug development, diagnostics, and therapeutic applications.
Furthermore, Pan has also innovated a method for the single-cell analysis of telomere length utilizing multiplex pre-PCR followed by quantitative PCR (SCT-pqPCR). This invention aids in understanding relative telomere length at the single-cell level, contributing to research in cellular aging and genomic stability.
Career Highlights
Xinghua Pan has had an impressive career with associations at prominent institutions, including Yale University and Molecular Staging Inc. His work at these organizations has been influential in advancing genomic research and methodology, solidifying his reputation as a leader in his field.
Collaborations
Throughout his career, Pan has collaborated with notable scientists such as Sherman M Weissman and Roger S Lasken. These collaborations have further enriched his research, allowing for the sharing of insights and advancements in genetic research methodologies.
Conclusion
Xinghua Pan's contributions to the field of genomics through his innovative patents significantly enhance our understanding of chromatin structure and DNA methylation at single-cell resolution. His work not only influences academic research but also has far-reaching implications for diagnostics and therapeutics, showcasing the vital role of inventors in the advancement of science and technology.