Title: Innovations and Contributions of Inventor Xiaowei Guo
Introduction
Xiaowei Guo is a notable inventor based in China, recognized for his contributions to biotechnology and fermentation processes. His work primarily focuses on the development of recombinant strains and methods for producing essential amino acids.
Latest Patents
Xiaowei Guo holds several innovative patents, including the "Escherichia Coli-Based Recombinant Strain, Construction Method Therefor And Use Thereof." This patent provides a nucleotide sequence formed by mutation of a base at the 1049th site of a wild-type deoB gene coding sequence. It also includes a promoter nucleotide sequence that has been mutated at the -67th site upstream of a specific nucleotide sequence. The invention encompasses an expression cassette, a recombinant protein, a recombinant vector, and a construction method for producing L-threonine through fermentation. Compared to an unmutated wild-type strain, the developed strain can produce L-threonine at a higher concentration, thereby reducing production costs and demonstrating good strain stability.
Another significant patent is the "Method For Producing L-Lysine By Modifying Aconitase Gene And/or Regulatory Elements Thereof." This method involves modifying the aconitase gene and/or its regulatory elements on a bacterial chromosome to reduce the enzymatic activity and/or expression quantity of aconitase without completely eliminating it. The modified bacteria can then be fermented to generate L-lysine, along with various methods and uses derived from this process.
Career Highlights
Xiaowei Guo has worked with several companies, including Gmedia Technology Co., Ltd. and Beijing Sigone Venture Limited. His experience in these organizations has contributed to his expertise in biotechnology and fermentation technology.
Collaborations
Xiaowei has collaborated with notable colleagues such as Wei Shen and Jiabing Liu, enhancing his research and development efforts in the field.
Conclusion
Xiaowei Guo's innovative work in biotechnology, particularly in the development of recombinant strains and fermentation methods, showcases his significant contributions to the field. His patents reflect a commitment to advancing production techniques for essential amino acids, which can have a lasting impact on the industry.