Xiaofan Dong

Title: Innovations of Xiaofan Dong in Biochip Technology

Introduction

Xiaofan Dong is a prominent inventor based in San Diego, California. He has made significant contributions to the field of biochip technology, holding two patents that showcase his innovative approach to biomolecular assays. His work is instrumental in advancing the capabilities of biochips for various applications.

Latest Patents

Xiaofan Dong's latest patents include a groundbreaking design for three-dimensional format biochips. This biochip is formed with a plurality of optically clear hydrogel cells attached to the top surface of a solid substrate in the form of an array. Each cell is constructed from a hydrogel of polyethylene glycol, polypropylene glycol, or a copolymer thereof, featuring reactive isocyanate groups. Binding entities are immobilized within these cells, allowing them to selectively hybridize to or sequester target biomolecules. By immobilizing different binding entities in various cells within the array, the biochip can be utilized to assay multiple target biomolecules simultaneously.

Another notable patent involves methods and gel compositions for encapsulating living cells and organic molecules. This method encapsulates biologics within a hydrogel using an aqueous solution of an isocyanate-functional hydrogel prepolymer mixed with biologics and a dithiol crosslinking agent under physiological pH conditions. The resulting product can serve as a bioreactor or an assay device, featuring a variety of biologics encapsulated at predetermined locations within a substrate.

Career Highlights

Xiaofan Dong is currently employed at Biocept, Inc., where he continues to develop innovative solutions in the field of biochips. His work has positioned him as a key figure in the advancement of biomolecular technologies.

Collaborations

Xiaofan collaborates with talented professionals in his field, including Soonkap Hahn and Roberto Fagnani. Their combined expertise contributes to the innovative projects at Biocept, Inc.

Conclusion

Xiaofan Dong's contributions to biochip technology through his patents and work at Biocept, Inc. highlight his role as an influential inventor in the field. His innovative approaches are paving the way for future advancements in biomolecular assays.