Xiaodong Zhang

Title: Innovations of Xiaodong Zhang in Serotonergic Research

Introduction

Xiaodong Zhang is a prominent inventor based in Durham, NC, known for his significant contributions to the field of serotonergic research. He holds three patents that focus on the genetic and biochemical mechanisms underlying serotonin synthesis in the brain. His work has implications for understanding and treating various neurological disorders.

Latest Patents

One of Zhang's latest patents describes transgenic mice carrying functional single nucleotide polymorphisms in brain-specific tryptophan hydroxylase. This invention involves recombinant or transgenic non-human mammals that possess a mutant tryptophan hydroxylase 2 (Tph2) gene, which alters the synthesis of 5-hydroxytryptophan and serotonin in the brain. The patent outlines methods for screening compounds for serotonergic activity, which includes administering a test compound to a recombinant non-human mammal and detecting serotonergic activity. Another patent focuses on polymorphisms in tryptophan hydroxylase-2, providing a method for screening subjects for serotonergic neurotransmission dysregulation disorders by detecting Tph2 mutations.

Career Highlights

Xiaodong Zhang is affiliated with Duke University, where he conducts his research and develops his innovative ideas. His work has garnered attention in the scientific community for its potential to advance the understanding of serotonin-related disorders.

Collaborations

Zhang has collaborated with notable researchers, including Marc G Caron and Martin Beaulieu, contributing to a rich exchange of ideas and advancements in the field.

Conclusion

Xiaodong Zhang's innovative research and patents in serotonergic mechanisms highlight his role as a key inventor in neuroscience. His contributions are paving the way for new treatments for serotonin-related disorders, showcasing the importance of genetic research in medicine.