The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 28, 2012
Filed:
Jul. 05, 2007
Marc G. Caron, Hillsborough, NC (US);
Xiaodong Zhang, Durham, NC (US);
Martin Beaulieu, Durham, NC (US);
Raul R. Gainetdinov, Chapel Hill, NC (US);
Tatyana D. Sotnikova, Chapel Hill, NC (US);
Marc G. Caron, Hillsborough, NC (US);
Xiaodong Zhang, Durham, NC (US);
Martin Beaulieu, Durham, NC (US);
Raul R. Gainetdinov, Chapel Hill, NC (US);
Tatyana D. Sotnikova, Chapel Hill, NC (US);
Duke University, Durham, NC (US);
Abstract
Recombinant or transgenic non-human mammals are described having a mutant tryptophan hydroxylase 2 (Tph2) gene resulting in altered synthesis of 5-hydroxytryptophan and serotonin in the brain. In some embodiments the mutant tryptophan hydroxylase 2 gene contains mouse R439H and/or P447R functional mutations, or their corresponding mutations in other species. Congenic non-human mammals having mutant tryptophan hydroxylase 2 genes are also provided. Methods of screening a compound for serotonergic activity or activity in treating a serotonergic neurotransmission dysregulation disorder are provided, which include administering a test compound to a recombinant non-human mammal and then detecting the presence or absence of serotonergic activity, or activity in treating a serotonergic neurotransmission dysregulation disorder, in the mammal. A cell such as a nerve cell (e.g., a central nervous system neuron) isolated from a transgenic or congenic mammal is also disclosed, along with cell cultures containing these cells.