Location History:
- Branford, CT (US) (1997 - 2007)
- Jackson, TN (US) (2007)
Company Filing History:
Years Active: 1997-2007
Title: Innovations by Xiao-shu He in the Field of Pharmaceutical Development
Introduction
Xiao-shu He is a prominent inventor based in Branford, Connecticut. He has made significant contributions to the field of pharmaceutical sciences, evident by the twenty patents he has secured throughout his career. His work focuses primarily on developing small molecule modulators that target specific biological receptors, which has important implications for treating various medical conditions.
Latest Patents
Among Xiao-shu He's latest patents, two notable inventions stand out. The first is the development of high affinity small molecule C5a receptor modulators. This invention presents low molecular weight, non-peptidic organic molecules that modulate mammalian complement C5a receptors. These molecules demonstrate several beneficial properties, such as being multi-aryl and heteroaryl in structure, which allows for effective inhibition of leukocyte chemotaxis at very low concentrations. Furthermore, this innovation has broad applications, including pharmaceutical compositions designed to treat inflammatory and immune system disorders.
The second invention pertains to melanin concentrating hormone receptor ligands, specifically substituted 1-benzyl-4-aryl-piperazine analogues. These ligands are capable of modulating the MCH receptor activity both in vivo and in vitro. They are particularly promising in treating metabolic, feeding, and sexual disorders not only in humans but also in domesticated and livestock animals. Additionally, the patent includes methods for utilizing these ligands in receptor localization studies.
Career Highlights
Xiao-shu He has established a remarkable career at Neurogen Corporation, where his research focuses on innovative pharmaceutical solutions. His portfolio of twenty patents reflects a commitment to advancing medical science through targeted receptor modulation. By exploring various chemical compounds and their interactions with biological systems, He has contributed to critical advancements in drug development.
Collaborations
Throughout his time at Neurogen Corporation, Xiao-shu He has collaborated with esteemed colleagues, including Brian de Costa and Andrew Y Thurkauf. These partnerships have enhanced his research, allowing for a richer exchange of ideas and approaches, which ultimately leads to more innovative solutions within the pharmaceutical industry.
Conclusion
In summary, Xiao-shu He's work has significantly impacted the landscape of pharmaceutical inventions. His innovative approach to developing small molecule modulators holds the potential to address a myriad of health challenges. With a strong patent portfolio and collaborative efforts with his peers, He continues to be a prominent figure in the realms of invention and innovation, paving the way for future breakthroughs in medicine.