Xiao-Bing Zhang

Title: Innovations in Gene Therapy by Xiao-Bing Zhang

Introduction

Xiao-Bing Zhang is a notable inventor based in Loma Linda, California. He has made significant contributions to the field of gene therapy, particularly in enhancing bone mass and strength. His innovative approaches have the potential to revolutionize treatments for bone-related conditions.

Latest Patents

Xiao-Bing Zhang holds a patent for a method titled "Systemic and local ex vivo gene therapy of the skeleton." This patent outlines methods for increasing bone mass and strength or facilitating bone fracture healing in subjects. The techniques involve administering a therapeutically effective amount of multipotent stem cells that are transformed with a recombinant nucleic acid molecule. This molecule includes a heterologous promoter linked to a nucleic acid encoding platelet-derived growth factor (PDGF) B. The multipotent stem cells are designed to express sufficient amounts of PDGFB to enhance bone mass and strength or promote healing of bone fractures. Additionally, a lentiviral vector is disclosed that features a phosphoglycerate kinase-1 (PGK) promoter linked to a nucleic acid encoding PDGFB.

Career Highlights

Throughout his career, Xiao-Bing Zhang has worked with esteemed organizations, including the United States Government as represented by the Department of Veterans Affairs and Loma Linda University. His work in these institutions has allowed him to advance his research and contribute to significant developments in gene therapy.

Collaborations

Xiao-Bing Zhang has collaborated with notable colleagues such as David J. Baylink and Kin-Hing William Lau. These partnerships have fostered a collaborative environment that enhances research outcomes and innovation in the field.

Conclusion

Xiao-Bing Zhang's contributions to gene therapy, particularly in bone health, highlight his role as an influential inventor. His innovative methods and collaborations continue to pave the way for advancements in medical treatments.