The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 17, 2017
Filed:
Nov. 04, 2015
The United States of America, As Represented BY the Department of Veterans Affairs, Washington, DC (US);
Loma Linda University, Loma Linda, CA (US);
David Baylink, Redlands, CA (US);
Kin-Hing William Lau, Redlands, CA (US);
Wanqiu Chen, Loma Linda, CA (US);
Xiao-Bing Zhang, Loma Linda, CA (US);
The United States of America as represented by the Department of Veteran Affairs, Washington, DC (US);
Loma Linda University, Loma Linda, CA (US);
Abstract
Methods are disclosed herein for increasing bone mass and strength or bone fracture healing in a subject. The methods include administering to the subject a therapeutically effective amount of multipotent stem cells, wherein each multipotent stem cell is transformed with a recombinant nucleic acid molecule comprising a heterologous promoter operably linked to a nucleic acid encoding platelet derived growth factor (PDGF) B, and wherein the multipotent stem cells express a sufficient amount of PDGFB to increase bone mass and strength or bone fracture healing. A lentiviral vector also is disclosed that includes a phosphoglycerate kinase-1 (PGK) promoter operably linked to a nucleic acid encoding PDGFB.