Xianhao Xu

Title: Xianhao Xu: Innovator in Biosensor Technology

Introduction

Xianhao Xu is a prominent inventor based in Wuxi, China. He has made significant contributions to the field of biosensor technology, particularly with his innovative work on pyruvate-responsive biosensors. His research focuses on the dynamic regulation of gene expression in cells, which has important implications for metabolic control.

Latest Patents

Xianhao Xu holds a patent for a "Pyruvate-responsive biosensor, and construction method and use thereof." This invention provides a method for constructing pyruvate-responsive biosensors with varying dynamic ranges. By optimizing the PdhR binding sequence and insertion site on the P43 promoter, Xu has achieved a minimum increase in dynamic range of 0.6 times and a maximum increase of 30.7 times. These biosensors are designed to precisely control gene expression based on the levels of pyruvate, a key metabolite in cellular metabolism. The biosensor demonstrates good specificity and operates within a response range of 10-35 nmol/g DCW.

Career Highlights

Xianhao Xu is affiliated with Jiangnan University, where he continues to advance his research in biosensor technology. His work has garnered attention for its potential applications in metabolic engineering and synthetic biology.

Collaborations

Xianhao Xu has collaborated with notable colleagues, including Long Liu and Jian Chen, to further enhance the development of biosensor technologies.

Conclusion

Xianhao Xu's innovative contributions to biosensor technology highlight the importance of dynamic regulation in cellular processes. His work not only advances scientific understanding but also opens new avenues for research and application in metabolic control.