Xiangdong W Yang

Title: Xiangdong W Yang: Innovator in Genetic Modification

Introduction

Xiangdong W Yang is a prominent inventor based in New York, NY (US). He has made significant contributions to the field of genetic engineering, holding a total of 5 patents. His work focuses on innovative methods for modifying nucleic acids and gene trapping, which have important implications in biotechnology and medicine.

Latest Patents

One of his latest patents is titled "Methods of performing homologous recombination based modification of nucleic acids in recombination deficient cells and use of the modified nucleic acid products thereof." This patent discloses a simple method for modifying genes in a recombination deficient host cell. The modifications include generating insertions, deletions, substitutions, and/or point mutations at any chosen site in the independent origin based cloning vector. The modified gene is contained in a cloning vector that can be used to introduce a modified heterologous gene into a cell. This modified vector may be utilized in the production of germline transmitted transgenic animals or in gene targeting protocols in eukaryotic cells. Notably, high throughput methodology is provided for generating the modified independent origin based cloning vectors.

Another significant patent is "Methods of performing gene trapping in bacterial and bacteriophage-derived artificial chromosomes and use thereof." This invention presents a method for efficiently sequencing multiple exons from complex genomic DNAs. The methodology employs bacterial and bacteriophage-derived artificial chromosomes (BBPACS) in novel gene trapping protocols. It includes targeted gene trapping by homologous recombination and random gene trapping using a transposon system. The patent also covers methods for preparing a gene map from BBPAC contigs and constructing cDNA libraries from these contigs.

Career Highlights

Xiangdong W Yang has worked at prestigious institutions, including The Rockefeller University. His research has significantly advanced the understanding of genetic modification techniques, making him a key figure in the field.

Collaborations

Throughout his career, Yang has collaborated with notable scientists such as Nathaniel Heintz and Weining Jiang. These collaborations have further enriched his research and contributed to the development of innovative genetic engineering methods.

Conclusion

Xiangdong W Yang is a distinguished inventor whose work in genetic modification has paved the way for advancements in biotechnology. His patents reflect a deep understanding of genetic engineering, and his contributions continue to influence the field