Xiafeng Lu

Title: **Xiafeng Lu: Innovator in Nitrilase Engineering**

Introduction

Xiafeng Lu is a distinguished inventor based in Hangzhou, China, recognized for his contributions to the field of bioengineering. With a focus on enzyme engineering, Lu has developed a unique nitrilase mutant that showcases significant advancements in catalyzing important chemical reactions.

Latest Patents

Lu holds one notable patent titled "Nitrilase mutant, construction method therefor, and application thereof." This innovative development outlines the construction method of a nitrilase mutant and its specific applications in synthesizing a chiral intermediate of pregabalin. The invention entails the use of turnip nitrilase (BrNIT) and Arabidopsis nitrilase (AtNIT) as parent enzymes. By employing a peptide fragment displacement method, Lu has successfully altered specific sites within the amino acid sequences of these nitrilases to create mutants that exhibit enhanced catalytic activity. Compared to the wild-type nitrilase, the mutants show substantial improvements in both activity and stereoselectivity, making them promising candidates for industrial applications.

Career Highlights

Xiafeng Lu is associated with Zhejiang University, where he engages in cutting-edge research and development within the realm of bioengineering. His work exemplifies the intersection of academic rigor and practical application, indicating a profound understanding of enzyme functionality and its implications in industrial settings.

Collaborations

Throughout his career, Lu has collaborated with talented colleagues such as Renchao Zheng and Yuguo Zheng. These partnerships have undoubtedly contributed to enhancing the scope and impact of his research efforts, fostering innovation in the field of bioengineering.

Conclusion

In summary, Xiafeng Lu stands out as an influential inventor in the bioengineering landscape. His patented nitrilase mutant not only showcases his inventive capabilities but also highlights the potential for advancements in chemical synthesis that meet industrial demands. As he continues to develop innovative solutions in biotechnology, his work is anticipated to have lasting implications in various applications.