Wolfgang Deger

Title: **The Innovations of Wolfgang Deger**

Introduction

Wolfgang Deger is a notable inventor based in Frankfurt-am-Main, Germany. With a portfolio of five patents, he has significantly contributed to the field of biopharmaceuticals, specifically focusing on controlled drug release systems. His innovative approaches are aimed at improving the efficacy and stability of LHRH antagonists.

Latest Patents

Wolfgang Deger's latest patents revolve around the development of a release-delaying system for LHRH antagonists, particularly cetrorelix. This invention allows for the controlled release of the active compound over several weeks through complexation with selected biophilic carriers, specifically acidic polyamino acids such as polyglutamic acid and polyaspartic acid. The preparation of cetrorelix polyamino acid complexes is achieved by combining aqueous solutions and precipitating the complexes, which are then centrifuged and dried under vacuum. If defined composition complexes are necessary, lyophilization serves as an effective method. The random liberation system has shown promising release-delaying properties based on the hydrophobicity and molecular mass of the polymers used. Animal studies have confirmed the activity of the cetrorelix-polyamino acid complexes as a depot system, achieving testosterone suppression in male rats over a duration of 600 hours. This key finding highlights the potential for controlled release through the selection of polymers.

Career Highlights

Wolfgang is affiliated with Asta Medica, Aktiengesellschaft, where he contributes his expertise as an inventor. His innovative work in controlled drug delivery systems stands out as a significant milestone in pharmaceutical research and its applications in therapeutics.

Collaborations

Throughout his career, Wolfgang has collaborated with other esteemed professionals in the field, including Jurgen Engel and Elisabeth Wolf-Heuss. These collaborations have likely enhanced the scope and impact of his research, fostering a productive environment for innovation in the pharmaceutical industry.

Conclusion

Wolfgang Deger is a remarkable inventor whose work has the potential to shape the future of drug delivery systems. His commitment to advancing biopharmaceutical technologies is evident through his patents and collaborations, making him an influential figure in his field. As the pharmaceutical landscape evolves, innovations like those developed by Deger will continue to play a crucial role in enhancing therapeutic outcomes for patients worldwide.