Company Filing History:
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Years Active: 2007-2020
Title: Wolfgang Buckel: A Pioneer in Itaconic Acid Production and Disease Detection
Introduction
Wolfgang Buckel, based in Marburg, Germany, is a renowned inventor with a notable portfolio of 13 patents. His innovative work has significantly contributed to advancements in biochemistry, specifically in the production of itaconic acid and the detection of critical metabolites related to health.
Latest Patents
Among Wolfgang Buckel's latest inventions is the method for itaconic acid production, which includes the development of nucleic acids encoding aconitate-delta-isomerase (ADI) and trans-aconitate decarboxylase (TAD). This invention also introduces a recombinant host cell engineered to overexpress these nucleic acids, alongside an expression cassette and vector integral to the process.
Another significant patent developed by Buckel focuses on the determination of (D)-2-hydroxyglutarate (D2HG) or (D)-2-hydroxyadipic acid. This method provides a nuanced approach for detecting these metabolites in a sample through a reagent mixture that contains a specific dye, an electron transfer agent, and a cofactor, among other components. This invention not only aids in diagnosing related diseases but also facilitates the identification of mutations in isocitrate dehydrogenase (IDH) gene or (D)-2-hydroxyglutarate dehydrogenase enzyme gene in subjects.
Career Highlights
Wolfgang Buckel's career has been marked by his work in prominent research-focused companies, including Cargill Inc. and the Deutsches Krebsforschungszentrum. His contributions in these roles have propelled advancements in biochemistry and molecular biology, particularly in developing methods that intersect with health diagnostics.
Collaborations
Throughout his career, Buckel has collaborated with esteemed colleagues such as Ravi R Gokarn and Olga V Selifonova. These partnerships have fostered a collaborative atmosphere that has been central to the innovation processes leading to his groundbreaking patents.
Conclusion
In summary, Wolfgang Buckel stands out as a significant figure in the realm of scientific inventions. With a strong focus on itaconic acid production and health-related diagnostics, his patents reflect a commitment to driving innovation in biochemistry. His work not only enhances our understanding of essential metabolites but also contributes to global health advancements through improved diagnostic methods.