This inventor holds 2 USPTO granted patents. Top assignees: Cornell University, International Business Machines Corporation. Active years: 1987-1991.
Company Filing History:
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1 out of 166,264 
Years Active: 1987-1991
Title: Winfried Denk: Innovator in Laser Microscopy
Introduction
Winfried Denk is a prominent inventor known for his contributions to the field of laser microscopy. He is based in Zurich, Switzerland, and holds 2 patents that have significantly advanced the capabilities of imaging techniques in biological research.
Latest Patents
One of his latest patents is for Two-photon laser microscopy. This innovative technology allows a laser scanning microscope to produce molecular excitation in a target material through the simultaneous absorption of two photons. This method provides intrinsic three-dimensional resolution, enabling the visualization of living cells and other microscopic objects with remarkable clarity. The technique utilizes fluorophores that absorb at about half the laser wavelength, producing fluorescent images while minimizing photobleaching. The focused laser pulses facilitate three-dimensional spatially resolved photochemistry, which is particularly beneficial for the photolytic release of caged effector molecules.
Another significant patent is for a light waveguide with a submicron aperture. This device consists of an optically transparent body with a sharp tip and a polished flat end. A metallization layer on its surface is designed to be opaque, and by pressing the waveguide against a rigid plate, a tiny aperture is exposed at the tip. This aperture allows light to pass through, with its diameter carefully controlled between 10 and 500 nm. This waveguide can be integrated into semiconductor lasers used in optical storage devices.
Career Highlights
Winfried Denk has had a distinguished career, working with notable organizations such as IBM and Cornell University. His work has been instrumental in pushing the boundaries of optical imaging and microscopy.
Collaborations
Throughout his career, Denk has collaborated with esteemed colleagues, including Johannes Georg Bednorz and James P. Strickler. These collaborations have further enriched his research and innovations in the field.
Conclusion
Winfried Denk's contributions to laser microscopy and optical technologies have made a lasting impact on scientific research. His innovative patents continue to enhance our understanding of biological processes at the microscopic level.