Company Filing History:
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Years Active: 2006-2019
Title: The Innovative Contributions of William W. Kwok
Introduction
William W. Kwok is a prominent inventor based in Bellevue, WA (US), known for his significant contributions to the field of immunology. With a total of 4 patents, he has made strides in understanding and combating viral infections, particularly rhinovirus infections.
Latest Patents
Kwok's latest patents focus on compositions and methods for preventing and treating rhinovirus infections. His research includes an analysis of human CD4 T-cell epitopes of rhinovirus capsid proteins, identifying peptide epitopes of RV-A16 capsid proteins VP1 and VP2. The study revealed that circulating RV-A16-specific CD4 T cells in non-infected subjects targeted 10 unique epitopes with diverse HLA-DR binding capacity. These T-cell epitopes are localized to conserved regions significant to the virus and are enriched for HLA class I and II binding motifs. Furthermore, they were activated in vivo after experimental infection with RV-A16. The findings indicate that RV-A16 epitopes provide approximately 90% coverage of the US population, with evidence of cross-reactivity between RV-A16 and RV-A39. High-frequency circulating RV-specific memory Th1 cells in healthy individuals preferentially target a limited set of conserved epitopes, which can serve as potential vaccine candidates.
Career Highlights
Kwok has worked at notable institutions, including the Benaroya Research Institute at Virginia Mason. His work has significantly advanced the understanding of immune responses and the development of therapeutic strategies against viral infections.
Collaborations
Throughout his career, Kwok has collaborated with esteemed colleagues such as Erik Wambre and Gerald Nepom, contributing to a rich exchange of ideas and research findings.
Conclusion
William W. Kwok's innovative work in immunology and his patents on rhinovirus infections highlight his role as a key figure in advancing medical science. His contributions continue to pave the way for new therapeutic approaches and a deeper understanding of immune responses.