The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 22, 2006
Filed:
Apr. 05, 2002
William W. Kwok, Bellevue, WA (US);
Gerald Nepom, Bainbridge, WA (US);
John Gebe, Bothell, WA (US);
Helena Reijonen, Seattle, WA (US);
Andrew Liu, Seattle, WA (US);
William W. Kwok, Bellevue, WA (US);
Gerald Nepom, Bainbridge, WA (US);
John Gebe, Bothell, WA (US);
Helena Reijonen, Seattle, WA (US);
Andrew Liu, Seattle, WA (US);
Benaroya Research Institute at Virginia Mason, Seattle, WA (US);
Abstract
The present invention provides of using multimeric MHC class II/peptide complexes. In one aspect, methods provided for identifying MHC class II-restricted immune epitopes of a predetermined polypeptide antigen. Methods for identifying an immunostimulatory epitope for a predetermined polypeptide antigen are provided. In a related aspect, methods for screening a therapeutic polypeptide agent for an MHC class II epitope are provided. In other aspects, methods for modulating T cells and for determining or monitoring an MHC class II-restricted immune status of a patient are also provided.