San Diego, CA, United States of America

William S Shestowsky


Average Co-Inventor Count = 3.8

ph-index = 3

Forward Citations = 138(Granted Patents)


Company Filing History:


Years Active: 1993-2008

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5 patents (USPTO):Explore Patents

Title: Innovations by William S. Shestowsky

Introduction

William S. Shestowsky is a notable inventor based in San Diego, CA. He has made significant contributions to the field of immunology, particularly through his innovative patents. With a total of 5 patents, his work focuses on the development of antibodies that have potential therapeutic applications.

Latest Patents

One of his latest patents involves Anti-CD80 antibodies. This invention relates to the identification of macaque antibodies to human B7.1 and B7.2 by screening phage display libraries or monkey heterohybridomas obtained using B lymphocytes from B7.1 and/or B7.2 immunized monkeys. Specifically, the invention provides four monkey monoclonal antibodies—7B6, 16C10, 7C10, and 20C9—which inhibit the B7:CD28 pathway and function as effective immunosuppressants. Additionally, the invention includes the complete DNA and amino acid sequences of the light and heavy chains of three PRIMATIZED® antibodies derived from those monkey monoclonal antibodies that bind B7.1 and possibly B7.2. These PRIMATIZED® and monkey antibodies may be used as specific immunosuppressants for treating autoimmune diseases and preventing organ transplant rejection. Another significant patent focuses on methods for treating B cell lymphoma using CD80-specific antibodies.

Career Highlights

Throughout his career, William has worked with various companies, including Idec Pharmaceuticals Corporation. His innovative work has positioned him as a key figure in the development of immunotherapeutic agents.

Collaborations

William has collaborated with notable individuals in his field, including Darrell R. Anderson and Peter Brams. Their combined expertise has contributed to the advancement of his research and inventions.

Conclusion

William S. Shestowsky's contributions to immunology through his innovative patents highlight his role as a significant inventor in the field. His work continues to pave the way for advancements in medical treatments.

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