Location History:
- Verona, WI (US) (1987)
- Madison, WI (US) (1993 - 2015)
Company Filing History:
Years Active: 1987-2015
Title: Innovations of William M. Sugden
Introduction
William M. Sugden is a prominent inventor based in Madison, WI (US). He has made significant contributions to the field of biotechnology, holding a total of 7 patents. His work primarily focuses on recombinant DNA technology and gene therapy.
Latest Patents
Among his latest patents, Sugden has developed a recombinant vector that includes a DNA segment with a synthetic origin of DNA synthesis. This invention is capable of binding EBNA-1 and initiating DNA synthesis of linked sequences. The synthetic origin comprises at least two binding sites for EBNA-1, flanked by half-binding sites for TRF2 or other proteins that enhance EBNA-1's affinity. Additionally, he has created a non-cytotoxic oriP replicon, which encodes a derivative of EBNA-1 that supports extrachromosomal replication without activating transcription from host cell genes. These vectors can be utilized in vitro and in gene therapy applications.
Career Highlights
Sugden is associated with the Wisconsin Alumni Research Foundation, where he continues to advance his research and innovations. His work has had a profound impact on the development of gene therapy techniques and biotechnological applications.
Collaborations
He has collaborated with notable colleagues such as Gregory Dean Kennedy and Atsushi Jun Komano, contributing to various projects in the field of biotechnology.
Conclusion
William M. Sugden's innovative work in recombinant DNA technology and gene therapy has established him as a key figure in his field. His contributions continue to influence advancements in biotechnology and medicine.