Company Filing History:
Years Active: 2010-2014
Title: The Innovations of William M. Ladd
Introduction
William M. Ladd is an accomplished inventor based in Cambridge, MA (US). He holds a total of 4 patents that contribute significantly to the field of biological networks. His work focuses on methods for quantifying responses within these networks, showcasing his expertise and innovative thinking.
Latest Patents
One of Ladd's latest patents is a method for quantifying the amplitude of a response of a biological network. This method involves deriving one or more measurement signatures from a knowledge base of causal biological facts. A signature is defined as a collection of measured node entities and their expected directions of change concerning a reference node. The knowledge base may consist of a directed network of experimentally observed causal relationships among biological entities and processes, with the reference node representing a perturbation. The degree of activation of a signature is assessed by scoring one or more 'differential' data sets against the signature to compute an amplitude score. This amplitude score quantifies fold-changes of measurements in the signature. In one embodiment, the amplitude score is a weighted average of adjusted log-fold changes of measured node entities in the signature, where the adjustment applied to the log-fold changes is based on their expected direction of change. In an alternative embodiment, the amplitude score is based on quantity effects.
Career Highlights
Throughout his career, William M. Ladd has made significant contributions to the field of biological research. His innovative methods have paved the way for advancements in understanding biological networks and their responses.
Collaborations
Ladd has worked alongside notable colleagues such as Ty Matthew Thomson and Dexter Roydon Pratt. Their collaborations have further enhanced the impact of his inventions in the scientific community.
Conclusion
William M. Ladd's contributions to the field of biological networks through his patents and collaborations highlight his role as a leading inventor. His innovative methods continue to influence research and development in this important area.
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