William K. Keener is a notable inventor based in Idaho Falls, ID (US). He has made significant contributions to the field of biotechnology, particularly in the development of plasmids and methods for detecting enzymatic activity. With a total of 4 patents, his work has implications for therapeutic agents and diagnostic methods.

Latest Patents

Keener's latest patents include innovative plasmids encoding therapeutic agents. One of his key inventions is a plasmid that encodes a fusion protein containing DP178, which serves as a targeting moiety. This plasmid, known as pWKK-500, includes various components such as the ricin A chain, an HIV protease cleavable linker, and a truncated ricin B chain. Additionally, it features N-terminal extensions like the maltose binding protein and a Factor Xa protease site. The C-terminal extensions consist of a hydrophobic linker, an L domain motif peptide, a KDEL ER retention signal, and more. He has also developed derivatives of this plasmid, including pWKK-700 and pWKK-800, which incorporate different encoding sequences. Another significant patent involves a method for detecting N-glycosylase activity, which utilizes oligodeoxyribonucleotide substrates and DNA polymerase to identify enzymatic activity.

Career Highlights

Throughout his career, William K. Keener has worked with prominent organizations such as Battelle Energy Alliance, LLC and Bechtel BWXT Idaho, LLC. His experience in these companies has contributed to his expertise in biotechnology and patent development.

Collaborations

Keener has collaborated with various professionals in his field, including Thomas E. Ward, enhancing the scope and impact of his inventions.

Conclusion

William K. Keener's innovative work in biotechnology, particularly in plasmid development and enzymatic detection methods, showcases his significant contributions to the field. His patents reflect a commitment to advancing therapeutic and diagnostic technologies.