Company Filing History:
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Years Active: 1995-2002
Title: **William J. Larochelle: Innovator in Fusion Proteins and Immunoadhesins**
Introduction
William J. Larochelle, an accomplished inventor based in Gaithersburg, MD, has made significant contributions to the field of biotechnology with a focus on fusion proteins and immunoadhesins. With a total of six patents to his name, his work stands at the intersection of innovative medical applications and advanced molecular engineering.
Latest Patents
Among his latest patents, Larochelle has developed fusion proteins that encompass both antibody and nonantibody regions. His pioneering designs achieve high affinity characteristics similar to homodimers of IgG heavy chains, while also incorporating properties that enhance secretion and flexibility. These novel fusion proteins can effectively substitute monoclonal antibodies in various applications such as flow cytometry, immunohistochemistry, and ELISAs.
Another significant patent revolves around immunoadhesins, where Larochelle's invention includes a recombinant nucleic acid encoding an immunoadhesin that is integrated within an adenoviral nucleic acid. This design facilitates effective delivery and expression of immunoadhesins, which can be utilized to treat inflammatory conditions. The innovative methods developed by Larochelle provide robust screening techniques for bioactivity in these immunoadhesins.
Career Highlights
William J. Larochelle has had the privilege of working with esteemed organizations such as the Department of Health and Human Services in the United States. His contributions to these institutions highlight his role in advancing medical and biological sciences through patented inventions that address critical health challenges.
Collaborations
Larochelle's career has also featured collaborations with notable colleagues, including Stuart A. Aaronson and Jacalyn H. Pierce. These partnerships have fostered an environment of shared innovation, leading to the effective development of groundbreaking technologies in the field of immunology.
Conclusion
William J. Larochelle's innovative spirit and commitment to advancing healthcare technologies through his patents exemplify the pivotal role inventors play in shaping the future of medicine. His work on fusion proteins and immunoadhesins not only demonstrates the potential of biotechnology but also sets the foundation for future advancements in therapeutic applications.