William H Kelsey

Title: The Innovative Contributions of William H. Kelsey

Introduction

William H. Kelsey, an accomplished inventor based in Alameda, CA, holds an impressive portfolio of seven patents. His groundbreaking work primarily focuses on advancements in bioprocessing and protein production, significantly impacting the fields of biotechnology and medical research.

Latest Patents

Among Kelsey's latest innovations is the "Cryopreservation Bag Assembly for Mammalian Cell Lines." This invention introduces a novel cell freezing and storage bag assembly designed to facilitate the seed train expansion of mammalian cells. Constructed mainly from polytetrafluoroethylene fabric, the bag holds sufficient cells for direct inoculation into a bioreactor. Its design ensures that the cell suspension maintains a thin cross-section, minimizing potential contamination risks with a sterile-weldable transfer set. Kelsey's method for sealing the bag below the connection point ensures easy inoculation, with the inoculation line protected during freezing and storage.

Another significant patent is his "Expression System for Factor VIII," which outlines a protein-free production process for proteins exhibiting factor VIII procoagulant activity. This process involves deriving stable human cell clones capable of high productivity for B-domain deleted Factor VIII while adapting the cells to thrive in a medium devoid of plasma-derived proteins.

Career Highlights

Kelsey's impressive career includes tenures at notable organizations such as Diamond Scientific Company and Miles Inc. His contributions have played a pivotal role in advancing various biotechnological applications, particularly in cell culture and complex protein production methodologies.

Collaborations

Throughout his career, William H. Kelsey has worked alongside esteemed colleagues including Edmund P. Bass and Michael D. McFarland. Their collaborative efforts have strengthened the development of cutting-edge biotechnological solutions and enhanced the scope of research in their field.

Conclusion

William H. Kelsey's inventions reflect a significant commitment to innovation in biotechnology. His patents not only address current challenges in mammalian cell culture and protein production but also pave the way for future advancements in the medical and scientific communities. Through his work, Kelsey has established himself as a noteworthy inventor and contributor to the field.