Location History:
- Glasgow, GB (1997 - 2000)
- London, GB (1997 - 2000)
Company Filing History:
6 out of 112 
4 out of 4,179 
Years Active: 1997-2000
Title: **William Frederick Carman: Innovator in Hepatitis B Vaccine Development**
Introduction
William Frederick Carman, a notable inventor based in London, GB, is renowned for his contributions to the field of immunology, particularly in the development of vaccines against Hepatitis B. With a remarkable portfolio of 10 patents, Carman has been at the forefront of medical innovation, impacting the lives of many through his groundbreaking work.
Latest Patents
Carman's most recent patents reflect his commitment to advancing healthcare. One significant innovation is the development of a Hepatitis B vaccine featuring a variant HBsAg protein. This variant protein or fragment, referred to as vHBsAg, includes a modified determinant in which an amino acid other than glycine is present at position 145 of the HBsAg sequence. The vaccine comprising the vHBsAg not only acts as a preventive measure but also serves as a diagnostic kit for the in vitro detection of anti-vHBsAg antibodies. Additionally, he has developed binding molecules specifically for Hepatitis B escape mutants, which include monoclonal antibodies secreted by cell lines designed to bind to both variant and wild-type HBsAg, enhancing the effectiveness of Hepatitis B diagnostics.
Career Highlights
Carman's illustrious career includes significant affiliations with renowned institutions such as the Imperial College of Science, Technology and Medicine and Abbott Laboratories Corporation. His work at these prestigious establishments has undoubtedly contributed to his profound understanding of vaccine development and patent innovation.
Collaborations
Throughout his career, Carman has collaborated with esteemed colleagues such as Howard Christopher Thomas and Richard H Decker. Their joint efforts in research and development have fostered an innovative environment, leading to significant advancements in vaccine technology.
Conclusion
William Frederick Carman stands out as a pivotal figure in the field of vaccine invention, with a dedicated focus on addressing complex health challenges such as Hepatitis B. His innovative patents and collaborations demonstrate his tireless commitment to medical research, setting a high standard for future inventors in the industry.