This inventor holds 4 USPTO granted patents. Top assignee: University of California. Active years: 1992-1995.
Company Filing History:
Years Active: 1992-1995
Title: Innovations of William E Van Nostrand
Introduction
William E Van Nostrand is a notable inventor based in Irvine, CA. He has made significant contributions to the field of biomedical research, particularly in the development of monoclonal antibodies. With a total of 4 patents, his work has implications for diagnosing and understanding amyloidoses, including Alzheimer's disease.
Latest Patents
One of his latest patents is focused on a monoclonal antibody produced against the native β-amyloid precursor. This invention discloses a hybridoma that produces the antibody, which specifically binds to an epitope on native secreted forms of β-APP. A key characteristic of this antibody is its ability to bind to a protein in culture medium from neuroblastoma cells. This protein co-migrates with PN-2 isolated from human fibroblast cultures in non-reducing polyacrylamide gel electrophoresis. Additionally, the antibody selectively binds to neuritic plaques and is sensitive enough to detect secreted forms of β-APP in cerebrospinal fluid at concentrations as low as 3.75 µg/ml.
Another significant patent involves a method for diagnosing diseases associated with cerebrovascular deposition of amyloid. This method includes obtaining a sample of cerebrospinal fluid and measuring the level of immunoreactivity toward a monoclonal antibody raised against native PN-2/β-APP. The measured level is then compared to that in a sample from a control group.
Career Highlights
William E Van Nostrand has had a distinguished career at the University of California, where he has contributed to various research projects and innovations. His work has been pivotal in advancing the understanding of amyloid-related diseases.
Collaborations
Throughout his career, he has collaborated with notable colleagues, including Dennis D Cunningham and Steven L Wagner. These collaborations have further enriched his research and contributed to the success of his inventions.
Conclusion
William E Van Nostrand's innovative work in the field of monoclonal antibodies and amyloidosis diagnosis showcases his significant contributions to biomedical research. His patents reflect a commitment to advancing medical science and improving diagnostic methods for serious diseases.