Location History:
- Andover, MA (US) (2010 - 2011)
- North Andover, MA (US) (2007 - 2012)
Company Filing History:
3 out of 57 
2 out of 2,886 
2 out of 30 Years Active: 2007-2012
Title: Innovations of William C. Karl
Introduction
William C. Karl is a notable inventor based in North Andover, MA (US). He has made significant contributions to the field of biosensors, holding a total of seven patents. His work focuses on advanced methods for detecting spectral shifts and screening antibodies, which have important applications in medical diagnostics and research.
Latest Patents
One of his latest patents is titled "Method and apparatus for biosensor spectral shift detection." This invention involves performing high-resolution determination of the relative shift of the spectral properties of a biosensor. The shift in the resonance peak of the biosensor indicates the amount of material bound to its surface. A preferred biosensor used in this invention is a Guided Mode Resonant Filter Biosensor (GMRFB). In one aspect of the invention, curve fitting is utilized to determine the relative location of the spectrum of the unexposed biosensor compared to those spectra altered by the presence of bound materials. Additionally, alternative embodiments include using the cross-correlation function to detect spectral peak offsets and employing maximal likelihood estimation techniques to determine spectral shifts.
Another significant patent by Karl involves "Methods for screening cells and antibodies." This invention provides methods for detecting changes in cell growth patterns and allows for the screening of various antibodies in a single receptacle. It also includes methods for detecting specific binding of an antibody to a protein or cell, even when the antibody is part of a mixture containing many different antibodies.
Career Highlights
Throughout his career, William C. Karl has worked with several prominent organizations, including Sru Biosystems, Inc. and The General Hospital Corporation. His expertise in biosensor technology has positioned him as a key figure in the development of innovative diagnostic tools.
Collaborations
Karl has collaborated with notable colleagues such as Homer Pien and Peter Li. These partnerships have contributed to the advancement of his research and the successful development of his patented technologies.
Conclusion
William C. Karl's contributions to the field of biosensors and antibody screening demonstrate his innovative spirit and dedication to advancing medical technology. His patents reflect a commitment to improving diagnostic methods, which can have a lasting impact on healthcare.
Inventor’s Patent Attorneys refers to legal professionals with specialized expertise in representing inventors throughout the patent process. These attorneys assist inventors in navigating the complexities of patent law, including filing patent applications, conducting patent searches, and protecting intellectual property rights. They play a crucial role in helping inventors secure patents for their innovative creations.