Title: William A. Ernst: Innovator in Liposomal Vaccine Compositions
Introduction
William A. Ernst is an inventor based in Rancho Dominguez, CA (US). He is currently associated with Molecular Express, Inc. Although he has not yet been granted any patents, his work focuses on innovative solutions in the field of vaccine development.
Latest Patent Applications
One of his notable patent applications is titled "Liposomal Formulations." This invention relates to liposomal vaccine compositions, methods for their manufacture, and methods for their use to stimulate an immune response in an animal. The compositions comprise liposomes formed from dimyristoylphosphatidylcholine (DMPC), either dimyristoylphosphatidylglycerol (DMPG) or dimyristoyltrimethylammonium propane (DMTAP), or both DMPC and DMTAP, along with at least one sterol. Additionally, it includes an antigenic polypeptide comprising a first polypeptide sequence and a second polypeptide sequence that is heterologous to the first. This second sequence includes a transmembrane sequence from a membrane protein, which has a sufficient number of residues to cross a lipid bilayer, with at least nine contiguous residues predicted to form an alpha helix having a hydrophobicity score of about 0.7 or greater.
Conclusion
William A. Ernst is making significant contributions to the field of vaccine development through his innovative research and patent applications. His work in liposomal formulations holds promise for advancing immunological responses in animals.