Wilhelmus H J Boesten

Title: Wilhelmus H J Boesten: Innovator in Pharmaceutical Processes

Introduction

Wilhelmus H J Boesten is a notable inventor based in Sittard, Netherlands. He has made significant contributions to the field of pharmaceuticals, particularly in the development of processes for synthesizing important compounds. With a total of 7 patents to his name, Boesten's work has had a considerable impact on the industry.

Latest Patents

One of his latest patents is a process for the preparation of ampicillin. In this innovative method, ampicillin is produced through a batch process by enzymatic acylation of 6-aminopenicillanic acid (6-APA) using a phenylglycine derivative, such as D-phenylglycine amide. The process achieves high conversions of the phenylglycine derivative by maintaining a total concentration in the reaction mixture of 6-APA and ampicillin greater than 250 mM, with a molar ratio of less than 2.5. Additionally, higher yields of ampicillin are obtained when the amount of dissolved 6-APA is kept below 300 mM.

Another significant patent involves the preparation of optically active 2-amino-w-oxoalkanoic acid. This process includes converting the corresponding aldehyde into an acetal-protected aldehyde, which is then transformed into an aminonitrile. The aminonitrile is subsequently converted into an amino acid amide, which undergoes enzymatic, enantioselective hydrolysis. This results in the isolation of the (S)-amino acid, while the (R)-enantiomer remains intact.

Career Highlights

Throughout his career, Boesten has worked with prominent companies such as DSM N.V. and DSM IP Assets B.V. His experience in these organizations has allowed him to refine his skills and contribute to various innovative projects in the pharmaceutical sector.

Collaborations

Boesten has collaborated with notable colleagues, including Quirinus B Broxterman and Marcus J M Plaum. These partnerships have further enhanced his research and development efforts, leading to advancements in pharmaceutical processes.

Conclusion

Wilhelmus H J Boesten is a distinguished inventor whose work in pharmaceutical processes has led to significant advancements in the field. His innovative patents and collaborations reflect his commitment to