The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 18, 2006
Filed:
Dec. 10, 1999
Applicants:
Harold M. Moody, Maastricht, NL;
Wilhelmus H. J. Boesten, Sittard, NL;
Inventors:
Harold M. Moody, Maastricht, NL;
Wilhelmus H. J. Boesten, Sittard, NL;
Assignee:
DSM IP Assests B.V., Heerlen, NL;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 9/00 (2006.01);
U.S. Cl.
CPC ...
Abstract
Ampicillin is produced in a batch process by enzymatic acylation of 6-aminopenicillanic acid (6-APA) with the aid of phenylglycine derivative such as D-phenylglycine amide. High conversions of phenylglycine derivative may be achieved by having the total concentration in the reaction mixture of 6-APA and ampicillin greater than 250 mM and the molar ration of total quantity of phenylglycine derivative to total quantity of 6-APA less than 2.5. Higher yields of ampicillin may be achieved when the amount of dissolved 6-APA is kept low, e.g. below 300 mM.