Location History:
- Grafelfing, DE (1994 - 2005)
- Butzbach, DE (2011)
Company Filing History:
6 out of 1,289 
2 out of 893 
Years Active: 1994-2011
Title: Werner Risau: Innovator in Angiogenesis and Vasculogenesis
Introduction
Werner Risau is a prominent inventor known for his significant contributions to the fields of angiogenesis and vasculogenesis. Based in Grafelfing, Germany, he holds a total of 6 patents that focus on the modulation of these critical biological processes. His work has implications for various medical treatments, particularly in cancer therapy.
Latest Patents
Among his latest patents, Risau has developed a cell line comprising a vector encoding a truncated FLK-1 receptor. This invention relates to the use of ligands for the FLK-1 receptor, which plays a vital role in the modulation of angiogenesis and vasculogenesis. The research demonstrates that the expression of the Flk-1 tyrosine kinase receptor is associated with endothelial cells, identifying vascular endothelial growth factor (VEGF) as its high-affinity ligand. These findings underscore the importance of Flk-1 in the signaling system during vasculogenesis and angiogenesis. Furthermore, the engineering of host cells that express Flk-1 allows for the evaluation and screening of drugs and analogs of VEGF, which can modulate Flk-1 activity through either agonist or antagonist mechanisms. The invention also explores the therapeutic use of FLK-1 ligands, including VEGF agonists and antagonists, in treating disorders such as cancer by modulating these processes.
Career Highlights
Throughout his career, Risau has been associated with notable institutions, including the Max Planck Society for the Advancement of Science and Yissum Research Development Company of the Hebrew University of Jerusalem. His work has significantly advanced the understanding of vascular biology and its applications in medicine.
Collaborations
Risau has collaborated with esteemed colleagues such as Axel Ullrich and Birgit Millauer, contributing to the collective knowledge in the field of vascular research.
Conclusion
Werner Risau's innovative work in the modulation of angiogenesis and vasculogenesis has paved the way for potential advancements in cancer treatment and other medical applications. His contributions continue to influence the scientific community and enhance our understanding of vascular biology.