Wen Li

Title: Innovations by Inventor Wen Li

Introduction

Wen Li is an accomplished inventor based in Tampa, FL (US). She has made significant contributions to the field of capillary electrophoresis through her innovative patents. With a total of 2 patents, her work focuses on enhancing the extraction and preconcentration of amino acids.

Latest Patents

Wen Li's latest patents include a novel on-line method for the extraction and preconcentration of amino acids using sol-gel coated columns. This method is coupled to a conventional UV/vis detector and employs extraction, stacking, and focusing techniques in the preconcentration procedures. The sol-gel coatings are created using N-Octadecyldimethyl[3(trimethoxysilyl)proply]ammonium chloride (C-TMS) in the coating sol solutions. The resulting sol-gel coating carries a positive charge, which facilitates the extraction of amino acids by adjusting the pH of the samples to impart a net negative charge to the amino acids. A long plug of the sample is passed through the sol-gel coated capillary, allowing for electrostatic interaction between the positively charged sol-gel coating and the negatively charged amino acid molecules. The focusing of the extracted amino acids is achieved through desorption carried out by local pH change, providing a remarkable 150,000-fold enrichment effect for alanine.

Career Highlights

Wen Li is affiliated with the University of South Florida, where she continues to advance her research and innovations. Her work has garnered attention for its practical applications in biochemical analysis and detection.

Collaborations

Wen collaborates with notable colleagues, including Abdul John Malik and David P Fries, contributing to a dynamic research environment.

Conclusion

Wen Li's innovative work in capillary electrophoresis exemplifies the impact of her inventions on the field of biochemical analysis. Her contributions continue to pave the way for advancements in the extraction and preconcentration of amino acids.