Company Filing History:
Years Active: 1997-2008
Title: Weimin Zhong: Innovator in Liver Enriched Transcription Factors
Introduction
Weimin Zhong is a prominent inventor based in New York, NY, known for his significant contributions to the field of molecular biology. He has been awarded five patents, showcasing his innovative work in the study of liver enriched transcription factors.
Latest Patents
One of Zhong's latest patents focuses on the liver enriched transcription factor, HNF-4 (hepatocyte nuclear factor 4). This protein is enriched in liver extracts and is crucial for binding to sites necessary for the transcription of the transthyretin (TTR) and apolipoprotein CIII (apoCIII) genes. The research has led to the purification of the HNF-4 protein, which weighs 54 kD, and the isolation of a cDNA clone encoding this protein. HNF-4 is classified as a member of the steroid hormone receptor superfamily, distinguished by an unusual amino acid in the conserved "knuckle" of the first zinc finger (DGCKG). Notably, HNF-4 does not bind significantly to estrogen, thyroid hormone, or glucocorticoid response elements, suggesting it may represent a new subfamily. HNF-4 binds to its recognition site as a dimer and activates transcription in a sequence-specific manner in nonhepatic (HeLa) cells. The presence of HNF-4 mRNA in the kidney and intestine, alongside the liver, further emphasizes its biological significance.
Career Highlights
Zhong's career is marked by his association with The Rockefeller University, where he has conducted groundbreaking research. His work has not only advanced the understanding of liver transcription factors but has also contributed to the broader field of gene regulation.
Collaborations
Throughout his career, Zhong has collaborated with esteemed colleagues, including Frances M Sladek and James E Darnell, Jr. These collaborations have enriched his research and expanded the impact of his findings in the scientific community.
Conclusion
Weimin Zhong's innovative work in the field of liver enriched transcription factors has led to significant advancements in molecular biology. His contributions continue to influence research and understanding in gene regulation and transcription mechanisms.