Wei Wen Teo

Title: Innovations of Wei Wen Teo in Quantitative Methylation Detection

Introduction

Wei Wen Teo is an accomplished inventor based in Johor Bahru, Johor, Malaysia. He has made significant contributions to the field of molecular biology, particularly in the detection of tumor DNA. With a total of 2 patents, his work has the potential to advance cancer diagnostics and improve patient outcomes.

Latest Patents

One of Wei Wen Teo's latest patents is the "Quantitative multiplex methylation specific PCR method-CMethDNA." This innovative method quantitatively detects tumor DNA or other circulating DNAs in fluids such as serum or plasma at the lowest copy number. The cMethDNA method is unique compared to other PCR-based assays, as it incorporates a small number of copies of a synthetic polynucleotide standard (STDgene) added to an aliquot of patient serum. A cocktail of standards for multiple genes of interest (TARGETgene) is also included. After purifying the total DNA, a multiplex PCR is performed, co-amplifying the STDgene and TARGETgene with the same external primer set. The second nested PCR step involves real-time PCR, allowing for quantification of each gene in one well using two-color real-time PCR. This method represents a novel modification of the QM-MSP method, specifically designed for the quantitative detection of tumor DNA at the lowest reported copy number.

Career Highlights

Wei Wen Teo is affiliated with Johns Hopkins University, where he continues to contribute to research and innovation in molecular diagnostics. His work has garnered attention for its potential applications in clinical settings, particularly in cancer detection and monitoring.

Collaborations

He has collaborated with notable colleagues, including Saraswati Vaidyanathan Sukumar and Mary Jo Fackler, further enhancing the impact of his research through teamwork and shared expertise.

Conclusion

Wei Wen Teo's innovative approaches in the field of molecular biology, particularly through his patented methods, are paving the way for advancements in cancer diagnostics. His contributions are significant and hold promise for improving patient care in the future.