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Title: Wei Wang: Innovator in Peptide Therapeutics
Introduction
Wei Wang is a notable inventor based in Alameda, CA (US), recognized for his contributions to the field of peptide therapeutics. With a total of 3 patents, his work focuses on developing innovative solutions for metabolic diseases, particularly in the context of diabetes.
Latest Patents
One of Wei Wang's latest patents is centered around the Pituitary adenylate cyclase activating peptide (PACAP) receptor (VPAC2) agonist peptide. This invention provides novel peptides that function in vivo as agonists of the VPAC2 receptor. These insulin secretagogue polypeptides have been shown to lower blood glucose levels in vivo more effectively than controls upon glucose challenge. The polypeptides are stable in formulation and possess long half-lives, offering a new therapy for patients with decreased endogenous insulin secretion, especially type 2 diabetics. The invention includes a polypeptide selected from a specific group of VPAC2-related polypeptides or their functional equivalents. Additionally, it outlines a method for treating metabolic diseases in mammals by administering a therapeutically effective amount of these insulin secretagogue peptides. Methods for making the peptides, both recombinant and synthetic, are also disclosed.
Another significant patent by Wei Wang is for a stabilized interleukin 2 formulation. This stable pharmaceutical preparation comprises human interleukin-2 or a variant thereof, along with a stabilizing amount of histidine. A preferred formulation includes glycine and sucrose, featuring a variant of IL-2 with a single mutation, N88R. The formulation is lyophilized, and upon reconstitution with an aqueous diluent, it results in a solution with a pH ranging from about 5.0 to 6.5.
Career Highlights
Wei Wang has worked with prominent companies such as Bayer Corporation and Bayer Pharmaceuticals Corporation. His experience in these organizations has contributed significantly to his expertise in peptide therapeutics and pharmaceutical formulations.
Collaborations
Throughout his career, Wei Wang has collaborated with notable professionals, including Rajiv Nayar and Michael A. Shearer. These collaborations have further enhanced his research and development efforts in the field.
Conclusion
Wei Wang's innovative work in peptide therapeutics, particularly in developing treatments for metabolic diseases, showcases his significant contributions to the field. His patents reflect a commitment to