Company Filing History:
Years Active: 2019
Title: Innovations in Catalysis: The Contributions of Wei Liu
Introduction
Wei Liu is an accomplished inventor based in Simi Valley, California. He has made significant contributions to the field of catalysis, particularly in the area of asymmetric synthesis. His innovative work has led to advancements that are crucial for the development of new chemical processes.
Latest Patents
Wei Liu holds a patent for "Sulfoxide ligand metal catalyzed oxidation of olefins." This patent describes the enantioselective synthesis of isochroman motifs accomplished via Pd(II)-catalyzed allylic C—H oxidation from terminal olefin precursors. A novel chiral aryl sulfoxide-oxazoline (ArSOX) ligand was critical to the success of this goal. The allylic C—H oxidation reaction proceeds with the broadest scope and highest levels of asymmetric induction reported to date, achieving an average of 92% enantiomeric excess across 13 examples with at least 90% enantiomeric excess. Additionally, the patent discloses a C(sp)-N fragment coupling reaction between abundant terminal olefins and N-triflyl protected aliphatic and aromatic amines via Pd(II)/sulfoxide (SOX) catalyzed intermolecular allylic C—H amination. This process yields a range of 52 allylic amines with good yields, averaging 76%, and excellent regio- and stereoselectivity, with ratios exceeding 20:1 for linear to branched and E to Z configurations.
Career Highlights
Wei Liu is affiliated with the University of Illinois, where he continues to push the boundaries of chemical research. His work has not only contributed to academic knowledge but has also practical implications in various industrial applications.
Collaborations
Wei Liu has collaborated with notable researchers, including M Christina White and Stephen E Ammann. These collaborations have further enhanced the impact of his research in the field of catalysis.
Conclusion
Wei Liu's innovative contributions to catalysis, particularly through his patented work, demonstrate his significant role in advancing chemical synthesis techniques. His research continues to influence both academic and industrial practices in the field.