Company Filing History:
Years Active: 2017-2020
Title: Innovations of Wei Huang in Glycoengineering
Introduction
Wei Huang is an accomplished inventor based in Dundalk, MD (US), known for his significant contributions to the field of glycoengineering. With a total of three patents to his name, Huang has made strides in the synthesis and application of glycoproteins and glycopeptides.
Latest Patents
Huang's latest patents include a method for the chemoenzymatic synthesis of core fucosylated glycopeptides and glycoproteins. This innovative method involves providing an acceptor, such as a fucosylated GlcNAc-protein or fucosylated GlcNAc-peptide, and reacting it with a donor substrate that includes an activated oligosaccharide moiety. The process utilizes specific endoglycosidases to transfer the oligosaccharide moiety to the acceptor, resulting in the desired core-fucosylated glycoprotein or glycopeptide. Additionally, he has developed methods for remodeling fucosylated glycoproteins and antibodies to include predetermined sugar chains, enhancing their functionality.
Another notable patent focuses on chemoenzymatic glycoengineering of antibodies and Fc fragments. This invention provides recombinant Endo-S mutants that exhibit reduced hydrolysis activity while increasing transglycosylation activity. This allows for efficient glycosylation remodeling of IgG1-Fc domains, resulting in different antibody glycoforms with structurally defined Fc N-glycans.
Career Highlights
Wei Huang is affiliated with the University System of Maryland, where he continues to advance research in glycoengineering. His work has implications for various applications, including therapeutic antibodies and biopharmaceuticals.
Collaborations
Huang has collaborated with notable colleagues such as Lai-Xi Wang and John Giddens, contributing to the advancement of glycoengineering research.
Conclusion
Wei Huang's innovative work in the field of glycoengineering has led to significant advancements in the synthesis and application of glycoproteins and glycopeptides. His contributions are paving the way for future developments in biopharmaceuticals and therapeutic applications.