Wei-Chuan Sun

Title: Wei-Chuan Sun and Fluorescent Dye Innovation.

Introduction

Wei-Chuan Sun is an inventor associated with Eugene, Oregon, and Molecular Probes, Inc. His work includes fluorescent dye technologies designed to improve performance in biological and chemical applications. Sun is credited with 2 patents.

Latest Patents

Sun’s listed patents focus on fluorine-substituted fluorescent dyes and their derivatives.

“Fluorinated xanthene derivatives” describes fluoresceins and rhodols with fluorine substitutions on one or more aromatic carbons. The dyes are designed to offer greater photostability and reduced sensitivity to pH changes within the physiological range of 6–8 compared with non-fluorinated dyes. They are also described as exhibiting less quenching when conjugated to other substances. Potential uses include detectable tracers and conjugates of organic and inorganic substances.

“Derivatives of 6,8-difluoro-7-hydroxycoumarin” covers the coumarins and their derivatives, including reactive dyes, dye conjugates, and enzyme substrates. The described dyes typically offer greater photostability, lower physiological-range pH sensitivity, and less fluorescence quenching upon conjugation than non-fluorinated analogs. Their absorption and emission spectra closely match those of the non-fluorinated analogs, while their quantum yields are described as higher.

Career Highlights

Sun’s patent work reflects an emphasis on fluorescent compounds with properties suited to detection and labeling. The inventions address practical performance considerations, including photostability, pH sensitivity, fluorescence quenching, and quantum yield.

Collaborations

Sun’s listed coworkers include Kyle R. Gee and Richard P. Haugland. His company affiliation is Molecular Probes, Inc.

Conclusion

Wei-Chuan Sun’s patents describe fluorinated fluorescent dyes and coumarin derivatives developed to improve the performance of tracers, conjugates, and enzyme substrates.