Company Filing History:
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1 out of 832,812 Years Active: 1998-2002
Title: Wayne N Frankel: Innovator in Neuronal Research
Introduction
Wayne N Frankel is a notable inventor based in Bar Harbor, ME (US). He has made significant contributions to the field of neuronal research, holding 2 patents that focus on critical aspects of neuronal voltage-gated calcium channels and associated disorders.
Latest Patents
Frankel's latest patents include groundbreaking work on genes encoding neuronal voltage-gated calcium channel gamma subunits. This patent discloses mammalian nucleic acid sequences that encode a neuronal-specific subunit of a voltage-gated calcium channel. The invention includes the gamma subunits and relates to expression vectors that encode these subunits, as well as cells containing such vectors. Additionally, it discusses antigenic fusion proteins that comprise portions of the mammalian neuronal-specific subunit, which are useful in producing antibodies that react specifically with these subunits. The nucleic acid sequences have applications in screening for compounds that modulate the activity of neuronal voltage-gated calcium channels and in diagnostic methods for autoimmune diseases like Lambert-Eaton Syndrome. Furthermore, they can be used in therapeutic methods for treating disorders related to these channels.
Another significant patent involves an in vitro method for identifying clinical disorders associated with the Nhe1 gene. This patent identifies a mutation responsible for ataxia and epilepsy in a murine model system. The specific mutation is an A to T transition at nucleotide 1639, which creates a premature stop codon. This discovery enables methods for detecting clinical disorders associated with defects in cation exchangers like Nhe1.
Career Highlights
Throughout his career, Frankel has worked with reputable organizations, including The Jackson Laboratory. His work has significantly advanced the understanding of neuronal functions and disorders.
Collaborations
Frankel has collaborated with notable colleagues such as Verity A Letts and Kevin P Campbell, contributing to the advancement of research in his field.
Conclusion
Wayne N Frankel's innovative work in neuronal research has led to important patents that enhance our understanding of neuronal functions and related disorders. His contributions continue to impact the scientific community and pave the way for future advancements in the field.