Company Filing History:
Years Active: 2000-2001
Title: Warren E Schwartz: Innovator in Oligonucleotide Synthesis
Introduction
Warren E Schwartz is a notable inventor based in Boxborough, MA (US). He has made significant contributions to the field of oligonucleotide synthesis, holding 2 patents that showcase his innovative methods and techniques.
Latest Patents
One of his latest patents focuses on "Extremely high purity oligonucleotides and methods of synthesizing them using dimer blocks." This invention presents an improved method for synthesizing oligonucleotides by employing dinucleotides, or "dimer blocks," as the basic synthetic unit. The method results in oligonucleotides of extremely high purity, with the N-1 content being very low, generally less than 1-2% of the full-length oligonucleotide. The synthesis using dinucleotide phosphorothioates yields oligonucleotides with minimal phosphodiester content. Additionally, the amount of dimer required in each coupling step can be less than about 6, with a preference for about 2 equivalents. Notably, this synthesis can be conducted without the capping step that was previously considered necessary after each coupling.
Career Highlights
Warren E Schwartz has worked with several prominent companies in the biotechnology sector, including Hybridon, Inc. and Avecia Biotechnology, Inc. His work in these organizations has contributed to advancements in the synthesis of oligonucleotides and related technologies.
Collaborations
Throughout his career, Warren has collaborated with notable professionals in the field, including Jin-Yan Tang and Nandkumar Bongle. These collaborations have further enriched his research and development efforts.
Conclusion
Warren E Schwartz is a distinguished inventor whose work in oligonucleotide synthesis has led to significant advancements in the field. His innovative methods and collaborations continue to influence biotechnology and related industries.