Company Filing History:
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Years Active: 2016
Title: Wael R Abd-Elgaliel: Innovator in Protease Degradable Polypeptides
Introduction
Wael R Abd-Elgaliel is a notable inventor based in Houston, TX (US). He has made significant contributions to the field of biochemistry, particularly in the development of innovative polypeptides that have potential applications in cancer diagnosis and treatment.
Latest Patents
Abd-Elgaliel holds a patent for "Protease degradable polypeptides and uses thereof." This invention includes polypeptides that are selectively cleaved by cathepsin E. The patent outlines methods for detecting cathepsin E by contacting it with the provided polypeptides and detecting fluorescence. Additionally, it describes methods for diagnosing cancer or pre-cancerous conditions in a subject. The invention also features a multilayered nanoparticle, which consists of a negatively charged nanoparticle core coated with alternating positive and negative layers. The positive layer may include a positively charged protease degradable polypeptide, while the negative layer can comprise a negatively charged therapeutic agent. Furthermore, the patent provides methods for treating or preventing diseases characterized by the expression of a protease in a subject using the nanoparticle.
Career Highlights
Throughout his career, Wael R Abd-Elgaliel has worked with esteemed organizations such as The Methodist Hospital System and the University of Texas System. His work in these institutions has allowed him to collaborate with leading experts in the field and contribute to groundbreaking research.
Collaborations
Abd-Elgaliel has collaborated with notable colleagues, including Ching-Hsuan Tung and Craig D Logsdon. These partnerships have further enhanced his research and innovation in the field of protease degradable polypeptides.
Conclusion
Wael R Abd-Elgaliel is a distinguished inventor whose work on protease degradable polypeptides has the potential to revolutionize cancer diagnosis and treatment. His innovative approaches and collaborations continue to make a significant impact in the field of biochemistry.