Company Filing History:
Years Active: 1987-1991
Title: W Maxwell Cowan: Innovator in Anti-Rabies Vaccines
Introduction
W Maxwell Cowan is a notable inventor based in Cardiff by the Sea, CA (US). He has made significant contributions to the field of immunology, particularly in the development of anti-rabies vaccines. With a total of 3 patents, his work has the potential to enhance public health and safety.
Latest Patents
Cowan's latest patent focuses on synthetic peptide-based anti-rabies compositions and methods. This innovation identifies a sequence in the coat glycoprotein of the rabies virus as crucial for the virus's pathogenesis. The binding of the virus to the acetylcholine receptor at neuromuscular junctions is a key step prior to the virus's uptake into peripheral nerves. Based on this discovery, Cowan has developed synthetic peptide-based anti-rabies vaccines. The active ingredient in these vaccines is a synthetic protein that is a conjugate with an immunogenic carrier protein. This protein includes a sequence that is substantially similar to a significant portion of the acetylcholine receptor-binding segment of the rabies virus coat protein.
The invention also details the preparation of anti-rabies antisera and antibodies by injecting a mammal with the synthetic protein, inducing an immune response. Hybridomas that secrete anti-rabies antibodies are created using B cells immunized with the synthetic peptide or protein. The vaccines developed by Cowan aim to avoid the risks associated with currently available anti-rabies vaccines. The antisera and antibodies produced are therapeutically useful for inducing passive anti-rabies immunity in mammals exposed to the rabies virus. Additionally, they serve as diagnostic tools to determine if a mammal is rabid or has been exposed to live rabies virus.
Career Highlights
Cowan's career is marked by his dedication to advancing vaccine technology. His innovative approach to vaccine development has positioned him as a leader in the field of immunology.
Collaborations
Cowan has collaborated with notable colleagues, including James Warner Patrick and Stephen Fox Heinemann, further enhancing the impact of his research.
Conclusion
W Maxwell Cowan's contributions to the development of anti-rabies vaccines represent a significant advancement in public health. His innovative work continues to pave the way for safer and more effective immunization strategies against rabies.